Comparative in vitro quality evaluation of different brands of Ebastine 10 mg tablets commercially available in Bangladesh
This thesis is submitted in partial fulfilment of the requirements for the degree of Bachelor of Pharmacy, 2019.
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| Langue: | English |
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Brac University
2020
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| Accès en ligne: | http://hdl.handle.net/10361/13923 |
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10361-13923 |
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10361-139232020-08-08T21:01:19Z Comparative in vitro quality evaluation of different brands of Ebastine 10 mg tablets commercially available in Bangladesh Rahman, Saqib Haque, Md. Aminul Department of Pharmacy, Brac University Ebastine BCS class II drug In vitro quality evaluation Assay by UV-spectroscopy Dissolution profile Conventional oral dosage form This thesis is submitted in partial fulfilment of the requirements for the degree of Bachelor of Pharmacy, 2019. Cataloged from PDF version of thesis report. Includes bibliographical references (pages 57-63). The main purpose of this study was to evaluate and compare the quality control parameters of twelve different brands of ebastine tablets available in Bangladesh. Different in vitro quality parameters including weight variation, % friability, hardness, disintegration time, dissolution profile and potency were assessed according to the compendial procedures. According to BP specification, all tablets of each brand showed % weight variation within the range. All brands showed their friability within the USP designated limit of less than 0.5%. Within 30 minutes, tablets from all brands disintegrated completely which complies with BP and JP specifications and eight out of twelve brands could not meet the first stage dissolution test. Potency was calculated using UV-spectrometric method and tablets from all brands showed potency not less than 90%. The study illustrates that all brands of ebastine tablets showed acceptable results for the experiments performed except 1st stage dissolution test for few brands. Saqib Rahman B. Pharmacy 2020-08-08T13:47:45Z 2020-08-08T13:47:45Z 2019 2019-08 Thesis ID 15146048 http://hdl.handle.net/10361/13923 en Brac University theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. 63 pages application/pdf Brac University |
| institution |
Brac University |
| collection |
Institutional Repository |
| language |
English |
| topic |
Ebastine BCS class II drug In vitro quality evaluation Assay by UV-spectroscopy Dissolution profile Conventional oral dosage form |
| spellingShingle |
Ebastine BCS class II drug In vitro quality evaluation Assay by UV-spectroscopy Dissolution profile Conventional oral dosage form Rahman, Saqib Comparative in vitro quality evaluation of different brands of Ebastine 10 mg tablets commercially available in Bangladesh |
| description |
This thesis is submitted in partial fulfilment of the requirements for the degree of Bachelor of Pharmacy, 2019. |
| author2 |
Haque, Md. Aminul |
| author_facet |
Haque, Md. Aminul Rahman, Saqib |
| format |
Thesis |
| author |
Rahman, Saqib |
| author_sort |
Rahman, Saqib |
| title |
Comparative in vitro quality evaluation of different brands of Ebastine 10 mg tablets commercially available in Bangladesh |
| title_short |
Comparative in vitro quality evaluation of different brands of Ebastine 10 mg tablets commercially available in Bangladesh |
| title_full |
Comparative in vitro quality evaluation of different brands of Ebastine 10 mg tablets commercially available in Bangladesh |
| title_fullStr |
Comparative in vitro quality evaluation of different brands of Ebastine 10 mg tablets commercially available in Bangladesh |
| title_full_unstemmed |
Comparative in vitro quality evaluation of different brands of Ebastine 10 mg tablets commercially available in Bangladesh |
| title_sort |
comparative in vitro quality evaluation of different brands of ebastine 10 mg tablets commercially available in bangladesh |
| publisher |
Brac University |
| publishDate |
2020 |
| url |
http://hdl.handle.net/10361/13923 |
| work_keys_str_mv |
AT rahmansaqib comparativeinvitroqualityevaluationofdifferentbrandsofebastine10mgtabletscommerciallyavailableinbangladesh |
| _version_ |
1814309704860434432 |