Significance of using Poloxamer 407 and Lactose in ibuprofen in vitro solubility enhancement
This thesis is submitted in partial fulfilment of the requirements for the degree of Bachelor of Pharmacy, 2019.
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| Materyal Türü: | Tez |
| Dil: | English |
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Brac University
2020
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| Online Erişim: | http://hdl.handle.net/10361/13909 |
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10361-13909 |
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10361-139092020-08-06T21:01:26Z Significance of using Poloxamer 407 and Lactose in ibuprofen in vitro solubility enhancement Akhter, Fahima Afrose, Afrina Department of Pharmacy, Brac University Ibuprofen NSAIDs Poloxamer Lactose Solubility Ibuprofen--Medicine This thesis is submitted in partial fulfilment of the requirements for the degree of Bachelor of Pharmacy, 2019. Cataloged from PDF version of thesis report. Includes bibliographical references (pages 41-45). Ibuprofen is a widely used NSAID drugs dealing with mild to moderate pain formulated in numerous dosage forms. But ibuprofen has very poor solubility in water associated with minimal drug absorption hence leading to infrequent and low bioavailability. The following project was taken to determine the solubility profile of the drug in presence of poloxamer 407 and L- lactose as excipients since dissolution of orally taken dosage form principally depends on the solubility. While using poloxamer 407, ibuprofen solubility increases in presence of both co-solvents water and ethanol (in 10%and 20%). On the other hand, while using lactose, ibuprofen shows increased solubility profile in water. But even though ibuprofen has better solubility in ethanol, using lactose in 10% and 20% ethanol for ibuprofen did not show any significant solubility profile that may because of inadequate solubility of lactose in ethanol leads to super saturation of ethanol by lactose. Fahima Akhter B. Pharmacy 2020-08-06T10:53:47Z 2020-08-06T10:53:47Z 2019 2019-08 Thesis ID 12346004 http://hdl.handle.net/10361/13909 en Brac University theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. 51 pages application/pdf Brac University |
| institution |
Brac University |
| collection |
Institutional Repository |
| language |
English |
| topic |
Ibuprofen NSAIDs Poloxamer Lactose Solubility Ibuprofen--Medicine |
| spellingShingle |
Ibuprofen NSAIDs Poloxamer Lactose Solubility Ibuprofen--Medicine Akhter, Fahima Significance of using Poloxamer 407 and Lactose in ibuprofen in vitro solubility enhancement |
| description |
This thesis is submitted in partial fulfilment of the requirements for the degree of Bachelor of Pharmacy, 2019. |
| author2 |
Afrose, Afrina |
| author_facet |
Afrose, Afrina Akhter, Fahima |
| format |
Thesis |
| author |
Akhter, Fahima |
| author_sort |
Akhter, Fahima |
| title |
Significance of using Poloxamer 407 and Lactose in ibuprofen in vitro solubility enhancement |
| title_short |
Significance of using Poloxamer 407 and Lactose in ibuprofen in vitro solubility enhancement |
| title_full |
Significance of using Poloxamer 407 and Lactose in ibuprofen in vitro solubility enhancement |
| title_fullStr |
Significance of using Poloxamer 407 and Lactose in ibuprofen in vitro solubility enhancement |
| title_full_unstemmed |
Significance of using Poloxamer 407 and Lactose in ibuprofen in vitro solubility enhancement |
| title_sort |
significance of using poloxamer 407 and lactose in ibuprofen in vitro solubility enhancement |
| publisher |
Brac University |
| publishDate |
2020 |
| url |
http://hdl.handle.net/10361/13909 |
| work_keys_str_mv |
AT akhterfahima significanceofusingpoloxamer407andlactoseinibuprofeninvitrosolubilityenhancement |
| _version_ |
1814308137475244032 |