Comparison of mutation spectrum, hemoglobin profiles and hematological features between transfusion dependent and non-dependent patients of Hb E/β Thalassemia
This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Science in Biotechnology, 2019.
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Brac University
2020
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| Dostęp online: | http://hdl.handle.net/10361/13896 |
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10361-138962023-01-24T09:08:05Z Comparison of mutation spectrum, hemoglobin profiles and hematological features between transfusion dependent and non-dependent patients of Hb E/β Thalassemia Islam, Maliha Hossain, Mahboob Department of Mathematics and Natural Sciences, Brac University Haemoglobin E/β Thalassemia Non-transfusion dependent Thalassemia Disease severity Haemoglobin profiles Haematological features Thalassemia--Diagnosis This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Science in Biotechnology, 2019. Cataloged from PDF version of thesis. Includes bibliographical references (pages 44-46). Hemoglobin E/β Thalassemia is an inherited anemic genetic disorder that is highly prevalent in the Southern Asia part of the world. Bangladesh falls in the Thalassemia belt of the world. The clinical manifestation of this disease is widely heterogeneous. The patients are divided into three groups: severe, moderately severe and non-transfusion dependent. In Bangladesh, data about NTDT (Non-Transfusion Dependent Thalassemia) patients are scarce. However, studying NTDT patients is essential as the factors behind its widely variable clinical diversity are still unknown. Here, the mutation spectrum, hemoglobin profiles, and hematological features are compared between the transfusion-dependent and NTD patients to find a responsible factor behind the disease severity. Among the compared parameters, it had been found that Hb F and Hb E play a role in ameliorating the disease severity because the increase in gamma genes of Hb F decreases the α/β-chain imbalance and the high oxygen dissociation power of HbE. This study can be useful for the correct diagnosis of NTDT patients. Maliha Islam B. Biotechnology 2020-07-22T06:22:16Z 2020-07-22T06:22:16Z 2019 2019 Thesis ID 15136003 http://hdl.handle.net/10361/13896 en Brac University theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. 46 pages application/pdf Brac University |
| institution |
Brac University |
| collection |
Institutional Repository |
| language |
English |
| topic |
Haemoglobin E/β Thalassemia Non-transfusion dependent Thalassemia Disease severity Haemoglobin profiles Haematological features Thalassemia--Diagnosis |
| spellingShingle |
Haemoglobin E/β Thalassemia Non-transfusion dependent Thalassemia Disease severity Haemoglobin profiles Haematological features Thalassemia--Diagnosis Islam, Maliha Comparison of mutation spectrum, hemoglobin profiles and hematological features between transfusion dependent and non-dependent patients of Hb E/β Thalassemia |
| description |
This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Science in Biotechnology, 2019. |
| author2 |
Hossain, Mahboob |
| author_facet |
Hossain, Mahboob Islam, Maliha |
| format |
Thesis |
| author |
Islam, Maliha |
| author_sort |
Islam, Maliha |
| title |
Comparison of mutation spectrum, hemoglobin profiles and hematological features between transfusion dependent and non-dependent patients of Hb E/β Thalassemia |
| title_short |
Comparison of mutation spectrum, hemoglobin profiles and hematological features between transfusion dependent and non-dependent patients of Hb E/β Thalassemia |
| title_full |
Comparison of mutation spectrum, hemoglobin profiles and hematological features between transfusion dependent and non-dependent patients of Hb E/β Thalassemia |
| title_fullStr |
Comparison of mutation spectrum, hemoglobin profiles and hematological features between transfusion dependent and non-dependent patients of Hb E/β Thalassemia |
| title_full_unstemmed |
Comparison of mutation spectrum, hemoglobin profiles and hematological features between transfusion dependent and non-dependent patients of Hb E/β Thalassemia |
| title_sort |
comparison of mutation spectrum, hemoglobin profiles and hematological features between transfusion dependent and non-dependent patients of hb e/β thalassemia |
| publisher |
Brac University |
| publishDate |
2020 |
| url |
http://hdl.handle.net/10361/13896 |
| work_keys_str_mv |
AT islammaliha comparisonofmutationspectrumhemoglobinprofilesandhematologicalfeaturesbetweentransfusiondependentandnondependentpatientsofhbebthalassemia |
| _version_ |
1814307482965639168 |