Prevalence of Zika virus infection in patients with Guillain-Barre syndrome in Bangladesh
This thesis is submitted in partial fulfilment of the requirements for the degree of Bachelor of Science in Microbiology, 2019.
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Brac University
2020
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10361-138952020-07-21T21:01:15Z Prevalence of Zika virus infection in patients with Guillain-Barre syndrome in Bangladesh Matiur, Tabassum Binte Hossain, Mahboob Hossain, Mahboob Department of Mathematics and Natural Sciences, Brac University Guillain–Barre syndrome (GBS) Zika virus (ZV) Bangladesh Zika virus infection This thesis is submitted in partial fulfilment of the requirements for the degree of Bachelor of Science in Microbiology, 2019. Catalogued from PDF version of thesis. Includes bibliographical references (pages 37-46). Guillain–Barre syndrome (GBS) is an autoimmune disease where the immune system of the body attacks the peripheral nervous system causing demyelination of the axon. This is the leading cause of acute flaccid paralysis (AFP) in Bangladesh. Previous studies have established an association between Zika virus (ZV) infection and GBS in South America and Oceania. In Asia, recently, ZV is known to circulate widely, but the association with Guillain–Barre syndrome is unclear. This prospective study aimed to describe the clinical profile and the frequency of ZIKA virus infected pathophysiology of GBS in Bangladesh. Detailed information of the clinical presentation, electrophysiology, diagnosis, disease severity, and clinical course were obtained from 98 patients with GBS prospectively and followed up for 6 months using a standard questionnaire. In this study, ZV specific IgG and IgM antibody were detected by Elisa to distinguish GBS patients with prolonging and recent ZV infection respectively. Moreover, RT-PCR was performed to confirm if patients had recent ZV infection. Among the 98 patients 18 (18%) GBS patients had ZV infection for a long time. Among the 18 Zika IgG positive patients, 15 patients with GBS (83%) were male and 3 of them were female (17%). The majority of ZV IgG positive patients with GBS were adults with a mean age of 40 years, almost 67% (n=66) had reported with preceding event and more than 40% (n=8) had gastrointestinal diarrhea. Around 45% of the ZV-IgG positive patients with GBS develop axonal variants of GBS and 38% had demyelinating variants of GBS. 56% had cranial nerve involvement and only 6% had sensory deficits. The MRC score of weeks 13 and week 26 were compared to observe the rate of recovery between Zika positive and Zika negative patients, however, there was no significant difference (week 13, p-value=0.31326 and week 26, p-value=0.430478). In conclusion, we can say that ZV can be considered a causative agent of Guillain-Barre Syndrome and male population are more vulnerable. However, further studies are warranted to see why ZV infection is predominant in male GBS patients comparing to their female counterparts. Tabassum Binte Matiur B. Microbiology 2020-07-21T14:22:49Z 2020-07-21T14:22:49Z 2019 2019-10 Thesis ID 15126015 http://hdl.handle.net/10361/13895 en Brac University theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. 46 pages application/pdf Brac University |
| institution |
Brac University |
| collection |
Institutional Repository |
| language |
English |
| topic |
Guillain–Barre syndrome (GBS) Zika virus (ZV) Bangladesh Zika virus infection |
| spellingShingle |
Guillain–Barre syndrome (GBS) Zika virus (ZV) Bangladesh Zika virus infection Matiur, Tabassum Binte Prevalence of Zika virus infection in patients with Guillain-Barre syndrome in Bangladesh |
| description |
This thesis is submitted in partial fulfilment of the requirements for the degree of Bachelor of Science in Microbiology, 2019. |
| author2 |
Hossain, Mahboob |
| author_facet |
Hossain, Mahboob Matiur, Tabassum Binte |
| format |
Thesis |
| author |
Matiur, Tabassum Binte |
| author_sort |
Matiur, Tabassum Binte |
| title |
Prevalence of Zika virus infection in patients with Guillain-Barre syndrome in Bangladesh |
| title_short |
Prevalence of Zika virus infection in patients with Guillain-Barre syndrome in Bangladesh |
| title_full |
Prevalence of Zika virus infection in patients with Guillain-Barre syndrome in Bangladesh |
| title_fullStr |
Prevalence of Zika virus infection in patients with Guillain-Barre syndrome in Bangladesh |
| title_full_unstemmed |
Prevalence of Zika virus infection in patients with Guillain-Barre syndrome in Bangladesh |
| title_sort |
prevalence of zika virus infection in patients with guillain-barre syndrome in bangladesh |
| publisher |
Brac University |
| publishDate |
2020 |
| url |
http://hdl.handle.net/10361/13895 |
| work_keys_str_mv |
AT matiurtabassumbinte prevalenceofzikavirusinfectioninpatientswithguillainbarresyndromeinbangladesh |
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1814308547564929024 |