An In-Vitro Study to Investigate anti-inflammatory and thrombolytic activity of methanolic extract of blumea lacera leaves
This thesis is submitted in partial fulfilment of the requirements for the degree of Bachelor of Pharmacy, 2019.
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| Формат: | Диссертация |
| Язык: | English |
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Brac University
2020
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| Online-ссылка: | http://hdl.handle.net/10361/13770 |
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10361-13770 |
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10361-137702020-02-17T21:01:16Z An In-Vitro Study to Investigate anti-inflammatory and thrombolytic activity of methanolic extract of blumea lacera leaves Tahsin, Faria Department of Pharmacy, Brac University Anti-inflammation Thrombolytic Heat induced Hypotonicity Haemolysis Blumea lacera Aspirin Streptokinase Blood clot This thesis is submitted in partial fulfilment of the requirements for the degree of Bachelor of Pharmacy, 2019. Cataloged from PDF version of thesis report. Includes bibliographical references (pages 36-38). Blumea lacera is a genus flowering plant which is a valuable ayurvedic medicine for centuries. Phytochemical contents of Blumea lacera extract figured the presence of different biochemical components like alkaloids, steroids, terpenoids, flavonoids, glycosides, tannins and phenolic compounds. The aim of the current study was to investigate the anti-inflammatory and thrombolytic property of Blumea lacera by observing inhibition of cell lysis and percent clot lysis. Five different concentrations of Blumea lacera extract were used as a test drug and aspirin, streptokinase were used as a standard drug for two experiments. The study showed dose dependent manner of haemolysis inhibition and good clot lysis activity as well. The maximum membrane stabilization of extract was found 72.80% at 500 μg/mL conc. in heat induced process and 74.08% at 500 μg/mL conc. in hypotonicity induced process and 61.79% clot lysis by extracts were found. Blume lacera possess significant anti-inflammatory as well as thrombolytic activity. However, further investigation can be carried out on isolation of individual phytocomponents and haemolysis inhibition by in-vivo procedure. Sumaiya Ahmed B. Pharmacy 2020-02-17T06:03:20Z 2020-02-17T06:03:20Z 2019 2019-09 Thesis ID 15346018 http://hdl.handle.net/10361/13770 en Brac University theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. 38 pages application/pdf Brac University |
| institution |
Brac University |
| collection |
Institutional Repository |
| language |
English |
| topic |
Anti-inflammation Thrombolytic Heat induced Hypotonicity Haemolysis Blumea lacera Aspirin Streptokinase Blood clot |
| spellingShingle |
Anti-inflammation Thrombolytic Heat induced Hypotonicity Haemolysis Blumea lacera Aspirin Streptokinase Blood clot An In-Vitro Study to Investigate anti-inflammatory and thrombolytic activity of methanolic extract of blumea lacera leaves |
| description |
This thesis is submitted in partial fulfilment of the requirements for the degree of Bachelor of Pharmacy, 2019. |
| author2 |
Tahsin, Faria |
| author_facet |
Tahsin, Faria |
| format |
Thesis |
| title |
An In-Vitro Study to Investigate anti-inflammatory and thrombolytic activity of methanolic extract of blumea lacera leaves |
| title_short |
An In-Vitro Study to Investigate anti-inflammatory and thrombolytic activity of methanolic extract of blumea lacera leaves |
| title_full |
An In-Vitro Study to Investigate anti-inflammatory and thrombolytic activity of methanolic extract of blumea lacera leaves |
| title_fullStr |
An In-Vitro Study to Investigate anti-inflammatory and thrombolytic activity of methanolic extract of blumea lacera leaves |
| title_full_unstemmed |
An In-Vitro Study to Investigate anti-inflammatory and thrombolytic activity of methanolic extract of blumea lacera leaves |
| title_sort |
in-vitro study to investigate anti-inflammatory and thrombolytic activity of methanolic extract of blumea lacera leaves |
| publisher |
Brac University |
| publishDate |
2020 |
| url |
http://hdl.handle.net/10361/13770 |
| _version_ |
1814307794278416384 |