CAR-T cell Therapy in B-cell Lymphoma
This thesis is submitted in partial fulfilment of the requirements for the degree of Bachelor of Pharmacy, 2019.
| 主要作者: | |
|---|---|
| 其他作者: | |
| 格式: | Thesis |
| 语言: | English |
| 出版: |
Brac University
2020
|
| 主题: | |
| 在线阅读: | http://hdl.handle.net/10361/13678 |
| id |
10361-13678 |
|---|---|
| record_format |
dspace |
| spelling |
10361-136782020-01-26T21:01:10Z CAR-T cell Therapy in B-cell Lymphoma Faruk, Asef Rahman, Saif Shahriar Department of Pharmacy, Brac University Cancer CAR-T cell B-cell lymphoma Immunotherapy T-Lymphocytes Immunotherapy This thesis is submitted in partial fulfilment of the requirements for the degree of Bachelor of Pharmacy, 2019. Cataloged from PDF version of thesis report. Includes bibliographical references (pages 46-71). B-cell lymphoma continues to be difficult to treat, with insignificant advances seen in more than two decades despite improvements in initial treatment strategies across its subtypes. Developing new targeted therapies which have acceptable safety and toxicity profiles is critical for better survival chances of the patients. Immunotherapy provides promising possibilities for patients with different B-cell lymphomas. CAR-T cell therapy has emerged as a new generation of powerful immunotherapy that has demonstrated high response in clinical trial for different B-cell lymphoma patients. The process involves adoptive transfer of T cells engineered ex vivo to be redirected to cancer cells. Recent clinical trials have provided promising safety and efficacy data for different B-cell lymphomas which have garnered enthusiasm in the scientific community. This review discusses the design of CAR-T cell therapy, its clinical trials and safety and efficacy strategies for successful clinical and commercial translation. Asef Faruk B. Pharmacy 2020-01-26T06:24:35Z 2020-01-26T06:24:35Z 2019 2019-08 Thesis ID 15146002 http://hdl.handle.net/10361/13678 en Brac University theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. 71 pages application/pdf Brac University |
| institution |
Brac University |
| collection |
Institutional Repository |
| language |
English |
| topic |
Cancer CAR-T cell B-cell lymphoma Immunotherapy T-Lymphocytes Immunotherapy |
| spellingShingle |
Cancer CAR-T cell B-cell lymphoma Immunotherapy T-Lymphocytes Immunotherapy Faruk, Asef CAR-T cell Therapy in B-cell Lymphoma |
| description |
This thesis is submitted in partial fulfilment of the requirements for the degree of Bachelor of Pharmacy, 2019. |
| author2 |
Rahman, Saif Shahriar |
| author_facet |
Rahman, Saif Shahriar Faruk, Asef |
| format |
Thesis |
| author |
Faruk, Asef |
| author_sort |
Faruk, Asef |
| title |
CAR-T cell Therapy in B-cell Lymphoma |
| title_short |
CAR-T cell Therapy in B-cell Lymphoma |
| title_full |
CAR-T cell Therapy in B-cell Lymphoma |
| title_fullStr |
CAR-T cell Therapy in B-cell Lymphoma |
| title_full_unstemmed |
CAR-T cell Therapy in B-cell Lymphoma |
| title_sort |
car-t cell therapy in b-cell lymphoma |
| publisher |
Brac University |
| publishDate |
2020 |
| url |
http://hdl.handle.net/10361/13678 |
| work_keys_str_mv |
AT farukasef cartcelltherapyinbcelllymphoma |
| _version_ |
1814307638714826752 |