The role of SIRT6 in down regulation of colorectal cancer
This thesis is submitted in partial fulfilment of the requirements for the degree of Bachelor of Pharmacy, 2019.
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| स्वरूप: | थीसिस |
| भाषा: | English |
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Brac University
2020
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| ऑनलाइन पहुंच: | http://hdl.handle.net/10361/13672 |
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10361-136722020-01-23T21:01:10Z The role of SIRT6 in down regulation of colorectal cancer Hridita, Rubya Tasnim Alam, Marzia Department of Pharmacy, Brac University SIRT6 STRING KEGG pathway Colorectal cancer Tumorigenesis This thesis is submitted in partial fulfilment of the requirements for the degree of Bachelor of Pharmacy, 2019. Cataloged from PDF version of thesis. Includes bibliographical references (pages 35-41). This work is based on SIRT6 role in down regulation of colorectal cancer. Sirtuin 6 (SIRT6) is a nicotinamide adenine dinucleotide+ (NAD+) dependent enzyme and stress response protein which can play an important role in tumorigenesis. In this paper, the relation between SIRT6 and colorectal cancer has been discussed. For this purpose, STRING and KEGG pathway were used. The link between SIRT6 and 204 different proteins were determined and the confidence score was calculated using STRING. From this study, key proteins for colorectal cancer were identified using KEGG pathway. The study showed that MYC, PTEN, PI3K and mTOR were the therapeutic targets for SIRT6. Moreover, SIRT6 inhibits PI3K/Akt signaling pathway and thus inhibits cancer cell proliferation. It also inhibits mTOR signaling pathway resulting in cancer cell apoptosis. Thus, the current study proposes that upregulating the expression of SIRT6 can be used as a therapeutic tool in combatting colorectal cancer. Rubya Tasnim Hridita B. Pharmacy 2020-01-23T04:32:19Z 2020-01-23T04:32:19Z 2019 2019-09 Thesis ID 13146055 http://hdl.handle.net/10361/13672 en Brac University theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. 41 pages application/pdf Brac University |
| institution |
Brac University |
| collection |
Institutional Repository |
| language |
English |
| topic |
SIRT6 STRING KEGG pathway Colorectal cancer Tumorigenesis |
| spellingShingle |
SIRT6 STRING KEGG pathway Colorectal cancer Tumorigenesis Hridita, Rubya Tasnim The role of SIRT6 in down regulation of colorectal cancer |
| description |
This thesis is submitted in partial fulfilment of the requirements for the degree of Bachelor of Pharmacy, 2019. |
| author2 |
Alam, Marzia |
| author_facet |
Alam, Marzia Hridita, Rubya Tasnim |
| format |
Thesis |
| author |
Hridita, Rubya Tasnim |
| author_sort |
Hridita, Rubya Tasnim |
| title |
The role of SIRT6 in down regulation of colorectal cancer |
| title_short |
The role of SIRT6 in down regulation of colorectal cancer |
| title_full |
The role of SIRT6 in down regulation of colorectal cancer |
| title_fullStr |
The role of SIRT6 in down regulation of colorectal cancer |
| title_full_unstemmed |
The role of SIRT6 in down regulation of colorectal cancer |
| title_sort |
role of sirt6 in down regulation of colorectal cancer |
| publisher |
Brac University |
| publishDate |
2020 |
| url |
http://hdl.handle.net/10361/13672 |
| work_keys_str_mv |
AT hriditarubyatasnim theroleofsirt6indownregulationofcolorectalcancer AT hriditarubyatasnim roleofsirt6indownregulationofcolorectalcancer |
| _version_ |
1814309493188591616 |