Do side-effects reduce compliance to iron supplementation? a study of daily- and weekly-dose regimens in pregnancy
Side-effects of iron supplementation lead to poor compliance. A weekly-dose schedule of iron supplementation rather than a daily-dose regimen has been suggested to produce fewer side-effects, thereby achieving a higher compliance. This study compared side-effects of iron supplementation and their im...
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| Μορφή: | Άρθρο |
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2019
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| Διαθέσιμο Online: | http://hdl.handle.net/10361/13318 |
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10361-133182019-12-19T05:21:11Z Do side-effects reduce compliance to iron supplementation? a study of daily- and weekly-dose regimens in pregnancy Hyder, S.M. Ziauddin Persson, Lars Åke Chowdhury, AMR Ekström, Eva-Charlotte Iron supplementation Pregnancy Compliance Bangladesh Infants--Care. Iron deficiency anemia--Bangladesh. Rural women--Diseases--Bangladesh. Nutritionally induced diseases--Bangladesh. Side-effects of iron supplementation lead to poor compliance. A weekly-dose schedule of iron supplementation rather than a daily-dose regimen has been suggested to produce fewer side-effects, thereby achieving a higher compliance. This study compared side-effects of iron supplementation and their impact on compliance among pregnant women in Bangladesh. These women were assigned to receive either weekly doses of 2×60 mg iron (one tablet each Friday morning and evening) or a daily dose of 1×60 mg iron. Fifty antenatal care centres were randomly assigned to prescribe either a weekly- or a daily-supplementation regimen (86 women in each group). Side-effects were assessed by recall after one month of supplementation and used for predicting compliance in the second and third months of supplementation. Compliance was monitored using a pill bottle equipped with an electronic counting device that recorded date and time whenever the pill bottle was opened. Of five gastrointestinal side-effects (heartburn, nausea, vomiting, diarrhoea, or constipation) assessed, vomiting occurred more frequently in the weekly group (21%) than in the daily group (11%, p<0.05). Compliance (ratio between observed and recommended tablet intake) was significantly higher in the weekly-supplementation regimen (93%) than in the daily-supplementation regimen (61%, p<0.05). Overall, gastrointestinal side-effects were not significantly associated with compliance. However, the presence of nausea and/or vomiting reduced compliance in both the regimens—but only among women from the lower socioeconomic group. In conclusion, weekly supplementation of iron in pregnancy had a higher compliance compared to daily supplementation of iron despite a higher frequency of side-effects. The findings support the view that gastrointestinal side-effects generally have a limited influence on compliance, at least in the dose ranges studied. Efforts to further reduce side-effects of iron supplementation may not be a successful strategy for improving compliance and effectiveness of antenatal iron supplementation. 2019-12-19T05:08:32Z 2019-12-19T05:08:32Z 2002-06 Article Hyder, S., Persson, L., Chowdhury, A., & Ekström, E. (2002). Do Side-effects Reduce Compliance to Iron Supplementation? A Study of Daily- and Weekly-dose Regimens in Pregnancy. Journal of Health, Population and Nutrition, 20(2), 175-179. 20721315 http://hdl.handle.net/10361/13318 en https://www.jstor.org/stable/23498939 Springer |
| institution |
Brac University |
| collection |
Institutional Repository |
| language |
English |
| topic |
Iron supplementation Pregnancy Compliance Bangladesh Infants--Care. Iron deficiency anemia--Bangladesh. Rural women--Diseases--Bangladesh. Nutritionally induced diseases--Bangladesh. |
| spellingShingle |
Iron supplementation Pregnancy Compliance Bangladesh Infants--Care. Iron deficiency anemia--Bangladesh. Rural women--Diseases--Bangladesh. Nutritionally induced diseases--Bangladesh. Hyder, S.M. Ziauddin Persson, Lars Åke Chowdhury, AMR Ekström, Eva-Charlotte Do side-effects reduce compliance to iron supplementation? a study of daily- and weekly-dose regimens in pregnancy |
| description |
Side-effects of iron supplementation lead to poor compliance. A weekly-dose schedule of iron supplementation rather than a daily-dose regimen has been suggested to produce fewer side-effects, thereby achieving a higher compliance. This study compared side-effects of iron supplementation and their impact on compliance among pregnant women in Bangladesh. These women were assigned to receive either weekly doses of 2×60 mg iron (one tablet each Friday morning and evening) or a daily dose of 1×60 mg iron. Fifty antenatal care centres were randomly assigned to prescribe either a weekly- or a daily-supplementation regimen (86 women in each group). Side-effects were assessed by recall after one month of supplementation and used for predicting compliance in the second and third months of supplementation. Compliance was monitored using a pill bottle equipped with an electronic counting device that recorded date and time whenever the pill bottle was opened. Of five gastrointestinal side-effects (heartburn, nausea, vomiting, diarrhoea, or constipation) assessed, vomiting occurred more frequently in the weekly group (21%) than in the daily group (11%, p<0.05). Compliance (ratio between observed and recommended tablet intake) was significantly higher in the weekly-supplementation regimen (93%) than in the daily-supplementation regimen (61%, p<0.05). Overall, gastrointestinal side-effects were not significantly associated with compliance. However, the presence of nausea and/or vomiting reduced compliance in both the regimens—but only among women from the lower socioeconomic group. In conclusion, weekly supplementation of iron in pregnancy had a higher compliance compared to daily supplementation of iron despite a higher frequency of side-effects. The findings support the view that gastrointestinal side-effects generally have a limited influence on compliance, at least in the dose ranges studied. Efforts to further reduce side-effects of iron supplementation may not be a successful strategy for improving compliance and effectiveness of antenatal iron supplementation. |
| format |
Article |
| author |
Hyder, S.M. Ziauddin Persson, Lars Åke Chowdhury, AMR Ekström, Eva-Charlotte |
| author_facet |
Hyder, S.M. Ziauddin Persson, Lars Åke Chowdhury, AMR Ekström, Eva-Charlotte |
| author_sort |
Hyder, S.M. Ziauddin |
| title |
Do side-effects reduce compliance to iron supplementation? a study of daily- and weekly-dose regimens in pregnancy |
| title_short |
Do side-effects reduce compliance to iron supplementation? a study of daily- and weekly-dose regimens in pregnancy |
| title_full |
Do side-effects reduce compliance to iron supplementation? a study of daily- and weekly-dose regimens in pregnancy |
| title_fullStr |
Do side-effects reduce compliance to iron supplementation? a study of daily- and weekly-dose regimens in pregnancy |
| title_full_unstemmed |
Do side-effects reduce compliance to iron supplementation? a study of daily- and weekly-dose regimens in pregnancy |
| title_sort |
do side-effects reduce compliance to iron supplementation? a study of daily- and weekly-dose regimens in pregnancy |
| publisher |
Springer |
| publishDate |
2019 |
| url |
http://hdl.handle.net/10361/13318 |
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