Use of combination of satins as antagonists of SPARC in stomach cancer: an in silico study
This project report is submitted in partial fulfilment of the requirements for the degree of Bachelor of Pharmacy, 2019.
| Prif Awdur: | |
|---|---|
| Awduron Eraill: | |
| Fformat: | Project report |
| Iaith: | English |
| Cyhoeddwyd: |
Brac University
2019
|
| Pynciau: | |
| Mynediad Ar-lein: | http://hdl.handle.net/10361/12387 |
| id |
10361-12387 |
|---|---|
| record_format |
dspace |
| spelling |
10361-123872019-09-30T05:58:01Z Use of combination of satins as antagonists of SPARC in stomach cancer: an in silico study Rashed, Sadman Sakib Bin Kabir, Eva Rahman Siam, Mohammad Kawsar Sharif Department of Pharmacy, Brac University SPARC Statins Stomach / Gastric cancer Drug repurposing Molecular docking Protein-ligand interactions Stomach -- Cancer. This project report is submitted in partial fulfilment of the requirements for the degree of Bachelor of Pharmacy, 2019. Cataloged from PDF version of project report. Includes bibliographical references (pages 38-44). SPARC is a protein found in gastric cell line. It has a dual role of tumor suppression and tumor progression. Over expression of SPARC in gastric cell line can lead to Stomach / Gastric cancer which is one of the leading cause of death worldwide. Over the past few years, drug repurposing and other in silico computational techniques have been considered as an ideal approach to discover newer therapeutic alternatives to treat cancer like disease. The application of drug repurposing and molecular docking can play a major role to identify options in the treatment of Stomach / Gastric cancer. Over secretion of SPARC is responsible for Stomach / Gastric cancer. Antagonists of SPARC can be considered as a treatment of choice. In this study, various combination drugs were investigated by applying several in silico approaches. Different combinations of statin drugs were made and among them combination of (Atorvastatin + Pitavastatin) proved to have better antagonistic activity towards the targeted protein SPARC. The combination of (Atorvastatin + Pitavastatin) showed properties that make it a viable option to be considered in Stomach / Gastric cancer therapy with a binding affinity of -9.2 kcal/ mol. Sadman Sakib Bin Rashed B. Pharmacy 2019-07-17T09:31:19Z 2019-07-17T09:31:19Z 2019 2019-05 Project report ID 15146012 http://hdl.handle.net/10361/12387 en Brac University project reports are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. 44 pages application/pdf Brac University |
| institution |
Brac University |
| collection |
Institutional Repository |
| language |
English |
| topic |
SPARC Statins Stomach / Gastric cancer Drug repurposing Molecular docking Protein-ligand interactions Stomach -- Cancer. |
| spellingShingle |
SPARC Statins Stomach / Gastric cancer Drug repurposing Molecular docking Protein-ligand interactions Stomach -- Cancer. Rashed, Sadman Sakib Bin Use of combination of satins as antagonists of SPARC in stomach cancer: an in silico study |
| description |
This project report is submitted in partial fulfilment of the requirements for the degree of Bachelor of Pharmacy, 2019. |
| author2 |
Kabir, Eva Rahman |
| author_facet |
Kabir, Eva Rahman Rashed, Sadman Sakib Bin |
| format |
Project report |
| author |
Rashed, Sadman Sakib Bin |
| author_sort |
Rashed, Sadman Sakib Bin |
| title |
Use of combination of satins as antagonists of SPARC in stomach cancer: an in silico study |
| title_short |
Use of combination of satins as antagonists of SPARC in stomach cancer: an in silico study |
| title_full |
Use of combination of satins as antagonists of SPARC in stomach cancer: an in silico study |
| title_fullStr |
Use of combination of satins as antagonists of SPARC in stomach cancer: an in silico study |
| title_full_unstemmed |
Use of combination of satins as antagonists of SPARC in stomach cancer: an in silico study |
| title_sort |
use of combination of satins as antagonists of sparc in stomach cancer: an in silico study |
| publisher |
Brac University |
| publishDate |
2019 |
| url |
http://hdl.handle.net/10361/12387 |
| work_keys_str_mv |
AT rashedsadmansakibbin useofcombinationofsatinsasantagonistsofsparcinstomachcanceraninsilicostudy |
| _version_ |
1814309699772743680 |