Functional analysis of depression associated proteins: role of TRK, BDNF, CYP2B6, POLG, PICK1 Biomarkers for early detection and treatment of depression
This project report is submitted in partial fulfilment of the requirements for the degree of Bachelor of Pharmacy, 2018.
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BRAC University
2019
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| Online dostop: | http://hdl.handle.net/10361/11608 |
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10361-116082019-09-30T05:25:42Z Functional analysis of depression associated proteins: role of TRK, BDNF, CYP2B6, POLG, PICK1 Biomarkers for early detection and treatment of depression Jurashe, Partha Sanjana Siam, Mohammad Kawsar Sharif Department of Pharmacy, BRAC University TRK BDNF CYP2B6 POLG PICK1 Biomarkers Depression Affective disorders This project report is submitted in partial fulfilment of the requirements for the degree of Bachelor of Pharmacy, 2018. Catalogued from PDF version of project report. Includes bibliographical references (pages 36-45). Psychiatric diseases relentlessly distress the ability of work also productivity of a person’s life. Considering the phenotypic unpredictability amongst patients, it is very hard to understand the pathogenesis. The study aims to identify the pathways responsible for psychiatric disease, especially for depression. Initially 62 depression associated proteins were listed from the UniProt and then hub genes of those proteins were identified. For functional annotation analysis, proteins UniProt IDs were submitted to the Database for Annotation, Visualization and Integrated Discovery shortly known as DAVID. Gene ontologies, protein domains, and pathways were analyzed using the GO enrichment and KEGG. The functional annotation clustering identified a total of 150 GO terms clustered into 23 groups. The pathways, identified from the clustering and KEGG, were overlapped to construct a Protein Protein Interaction (PPI) network. Finally, the common pathways were separated and 300 selected anti-depressants drugs from 5 classes were docked with depression associated proteins such as iGluR DELTA-2 (PDB ID- 5KC8), Dopamine Receptor, D2 (PDB ID- 6CM4), Sodium Dependent Serotonin Transporter (PDB ID- 2KS9), Glutamate receptor ionotropic, NMDA 2B (PDB ID- 5EWL) etc. Six anti-depressant drugs such as sertraline carbamoyl, norethindrone, and aripiprazole had good binding affinities (-10.5, -10.4 and -9.3 respectively) with the proteins of interest. The study also revealed that biomarkers like, TRK, BDNF, CYP2B6, POLG, PICK1 could be suitable for early detection of depression. Building on these findings, studies could be designed to target and examine protein clusters to understand depression and its transduction targets to identify functional biomarkers for early diagnosis. Partha Sanjana Jurashe B. Pharmacy 2019-03-21T04:26:44Z 2019-03-21T04:26:44Z 2018 2018-09 Project report ID 14146015 http://hdl.handle.net/10361/11608 en BRAC University project reports are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. 45 pages application/pdf BRAC University |
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Brac University |
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Institutional Repository |
| language |
English |
| topic |
TRK BDNF CYP2B6 POLG PICK1 Biomarkers Depression Affective disorders |
| spellingShingle |
TRK BDNF CYP2B6 POLG PICK1 Biomarkers Depression Affective disorders Jurashe, Partha Sanjana Functional analysis of depression associated proteins: role of TRK, BDNF, CYP2B6, POLG, PICK1 Biomarkers for early detection and treatment of depression |
| description |
This project report is submitted in partial fulfilment of the requirements for the degree of Bachelor of Pharmacy, 2018. |
| author2 |
Siam, Mohammad Kawsar Sharif |
| author_facet |
Siam, Mohammad Kawsar Sharif Jurashe, Partha Sanjana |
| format |
Project report |
| author |
Jurashe, Partha Sanjana |
| author_sort |
Jurashe, Partha Sanjana |
| title |
Functional analysis of depression associated proteins: role of TRK, BDNF, CYP2B6, POLG, PICK1 Biomarkers for early detection and treatment of depression |
| title_short |
Functional analysis of depression associated proteins: role of TRK, BDNF, CYP2B6, POLG, PICK1 Biomarkers for early detection and treatment of depression |
| title_full |
Functional analysis of depression associated proteins: role of TRK, BDNF, CYP2B6, POLG, PICK1 Biomarkers for early detection and treatment of depression |
| title_fullStr |
Functional analysis of depression associated proteins: role of TRK, BDNF, CYP2B6, POLG, PICK1 Biomarkers for early detection and treatment of depression |
| title_full_unstemmed |
Functional analysis of depression associated proteins: role of TRK, BDNF, CYP2B6, POLG, PICK1 Biomarkers for early detection and treatment of depression |
| title_sort |
functional analysis of depression associated proteins: role of trk, bdnf, cyp2b6, polg, pick1 biomarkers for early detection and treatment of depression |
| publisher |
BRAC University |
| publishDate |
2019 |
| url |
http://hdl.handle.net/10361/11608 |
| work_keys_str_mv |
AT jurasheparthasanjana functionalanalysisofdepressionassociatedproteinsroleoftrkbdnfcyp2b6polgpick1biomarkersforearlydetectionandtreatmentofdepression |
| _version_ |
1814309487456026624 |