A review on successful approaches of converting adult somatic cells into induced pluripotent stem cells (iPSCs)
This project report is submitted in partial fulfilment of the requirements for the degree of Bachelor of Pharmacy, 2018.
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| Taal: | English |
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BRAC University
2018
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| Online toegang: | http://hdl.handle.net/10361/10913 |
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10361-109132019-09-30T06:13:50Z A review on successful approaches of converting adult somatic cells into induced pluripotent stem cells (iPSCs) Islam, Tashfia Talukder, Mesbah Department of Pharmacy, BRAC University Adult somatic cells Induced Pluripotent Stem Cells Stem cells Medical-- Research This project report is submitted in partial fulfilment of the requirements for the degree of Bachelor of Pharmacy, 2018. Catalogued from PDF version of project report. Includes bibliographical references (page 36-45). The induced pluripotent stem cells (iPSCs) are referred to as patient-specific equivalents of embryonic stem cells for the reason that they originate from somatic cells once the forced expression of pluripotency reprogramming factors Oct4, Sox2, Klf4 and c‐Myc are introduced. Moreover, iPSCs present exceptional opportunity for personalized cell therapies and thus play a major role in the field of regenerative medicine. In current years, iPSC technology has undergone significant development to conquer time-consuming and ineffective “reprogramming protocols” and to guarantee clinical-grade iPSCs and their functional derivatives. Latest improvements in iPSC technology incorporate better reprogramming methods utilizing novel delivery systems such as non‐integrating viral and non‐viral vectors, using mRNAs of defined factors, using microRNAs, cell extracts and recently the ground-breaking discovery of the method in which the cells activate their own genes to revert back to pluripotency. At the same time, as small chemical molecules, inhibitors of specific signaling or epigenetic regulators have become fundamental to iPSC reprogramming; they have the capability to substitute recognized reprogramming factors and further advance the reprogramming processes. Additionally, characterization of iPSCs has also been mentioned in this review for assessing the effectiveness and accuracy of the discussed reprogramming methods. Hence, in this piece of writing, we review the most up to date inventions of techniques in the iPSC field, a summary of all the various methods that had been employed by scientists over the past years for attaining iPSCs and the probable application of iPSCs, in the fields of cell therapy and tissue engineering. Tashfia Islam B. Pharmacy 2018-11-29T09:24:39Z 2018-11-29T09:24:39Z 2018 2018-09 Project report ID 13346041 http://hdl.handle.net/10361/10913 en BRAC University project reports are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. 45 pages application/pdf BRAC University |
| institution |
Brac University |
| collection |
Institutional Repository |
| language |
English |
| topic |
Adult somatic cells Induced Pluripotent Stem Cells Stem cells Medical-- Research |
| spellingShingle |
Adult somatic cells Induced Pluripotent Stem Cells Stem cells Medical-- Research Islam, Tashfia A review on successful approaches of converting adult somatic cells into induced pluripotent stem cells (iPSCs) |
| description |
This project report is submitted in partial fulfilment of the requirements for the degree of Bachelor of Pharmacy, 2018. |
| author2 |
Talukder, Mesbah |
| author_facet |
Talukder, Mesbah Islam, Tashfia |
| format |
Project report |
| author |
Islam, Tashfia |
| author_sort |
Islam, Tashfia |
| title |
A review on successful approaches of converting adult somatic cells into induced pluripotent stem cells (iPSCs) |
| title_short |
A review on successful approaches of converting adult somatic cells into induced pluripotent stem cells (iPSCs) |
| title_full |
A review on successful approaches of converting adult somatic cells into induced pluripotent stem cells (iPSCs) |
| title_fullStr |
A review on successful approaches of converting adult somatic cells into induced pluripotent stem cells (iPSCs) |
| title_full_unstemmed |
A review on successful approaches of converting adult somatic cells into induced pluripotent stem cells (iPSCs) |
| title_sort |
review on successful approaches of converting adult somatic cells into induced pluripotent stem cells (ipscs) |
| publisher |
BRAC University |
| publishDate |
2018 |
| url |
http://hdl.handle.net/10361/10913 |
| work_keys_str_mv |
AT islamtashfia areviewonsuccessfulapproachesofconvertingadultsomaticcellsintoinducedpluripotentstemcellsipscs AT islamtashfia reviewonsuccessfulapproachesofconvertingadultsomaticcellsintoinducedpluripotentstemcellsipscs |
| _version_ |
1814308880888365056 |