A prospective study on the efficiency of ciprofloxacin in combination with chloramphenicol and probiotics against multiple antibiotics resistant Klebsiella pneumoniae
This thesis report is submitted in partial fulfilment of the requirement for the degree of B.Sc in Microbiology, 2017.
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| Định dạng: | Luận văn |
| Ngôn ngữ: | English |
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BRAC University
2018
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| Truy cập trực tuyến: | http://hdl.handle.net/10361/10440 |
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10361-104402019-09-30T04:42:55Z A prospective study on the efficiency of ciprofloxacin in combination with chloramphenicol and probiotics against multiple antibiotics resistant Klebsiella pneumoniae Ahmed, Akash Hossain, M. Mahboob Department of Mathematics and Natural Sciences, BRAC University Pneumonia Ciprofloxacin Chloramphenicol Klebsiella pneumoniae Antibiotics This thesis report is submitted in partial fulfilment of the requirement for the degree of B.Sc in Microbiology, 2017. Catalogued from PDF version of thesis report. Includes bibliographical references (pages 35-40). Pneumonia is the single largest infectious cause of death in children worldwide. Not only children but also adult from all age groups can be suffered from pneumonia. Pneumonia is a form of acute respiratory infection that affects the lungs. One of the prime pathogens of this infection is Klebsiella pneumoniae. Apparently, it seems pretty uncomplicated to treat K. pneumoniae, however, it is more than challenging to combat because of antimicrobial resistance. The purpose of the study was to develop new approach to treat antibiotic resistant K. pneumoniae infection. This study aimed in quest of a drug to combine with ciprofloxacin, a broad spectrum antibiotic frequently used to treat lung infections. A total of 23 lung infection bacterial samples were collected and studied against 14 antibiotics of different classes. After primary screening of antibiotic susceptibility, they were categorized into multidrug resistant (MDR), extensively drug resistant (XDR) and pan drug resistant (PDR) pathogens where 9 isolates were MDR, 5 were XDR and 3 isolates were PDR. Furthermore, they were trialed in combination ciprofloxacin along with other 7 drugs in disk diffusion to explore synergistic effect. The combination of ciprofloxacin and moxifloxacin, ciprofloxacin and chloramphenicol and ciprofloxacin with probiotic was found to be synergic. Then the minimum inhibitory concentration test was done for the two combination Ciprofloxacin + chloramphenicol and ciprofloxacin + probiotic. When the individual MIC result was generated, the MIC of the respective combination was analyzed. Furthermore, the fractional inhibitory concentration (FIC) was calculated and in accordance with the results of FIC index, ciprofloxacin-chloramphenicol combination has shown value 0.4510 which revealed synergistic effect against multi drug resistant Klebsiella pneumoniae. Although, in vivo animal modelling is needed for further validation, this finding is indisputably a novel and great one to combat highly drug resistant Klebsiella pneumoniae in upcoming future. Akash Ahmed B. Science in Microbiology 2018-09-05T06:01:22Z 2018-09-05T06:01:22Z 2017 2017-12 Thesis ID 13226002 http://hdl.handle.net/10361/10440 en BRAC University theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. 40 pages application/pdf BRAC University |
| institution |
Brac University |
| collection |
Institutional Repository |
| language |
English |
| topic |
Pneumonia Ciprofloxacin Chloramphenicol Klebsiella pneumoniae Antibiotics |
| spellingShingle |
Pneumonia Ciprofloxacin Chloramphenicol Klebsiella pneumoniae Antibiotics Ahmed, Akash A prospective study on the efficiency of ciprofloxacin in combination with chloramphenicol and probiotics against multiple antibiotics resistant Klebsiella pneumoniae |
| description |
This thesis report is submitted in partial fulfilment of the requirement for the degree of B.Sc in Microbiology, 2017. |
| author2 |
Hossain, M. Mahboob |
| author_facet |
Hossain, M. Mahboob Ahmed, Akash |
| format |
Thesis |
| author |
Ahmed, Akash |
| author_sort |
Ahmed, Akash |
| title |
A prospective study on the efficiency of ciprofloxacin in combination with chloramphenicol and probiotics against multiple antibiotics resistant Klebsiella pneumoniae |
| title_short |
A prospective study on the efficiency of ciprofloxacin in combination with chloramphenicol and probiotics against multiple antibiotics resistant Klebsiella pneumoniae |
| title_full |
A prospective study on the efficiency of ciprofloxacin in combination with chloramphenicol and probiotics against multiple antibiotics resistant Klebsiella pneumoniae |
| title_fullStr |
A prospective study on the efficiency of ciprofloxacin in combination with chloramphenicol and probiotics against multiple antibiotics resistant Klebsiella pneumoniae |
| title_full_unstemmed |
A prospective study on the efficiency of ciprofloxacin in combination with chloramphenicol and probiotics against multiple antibiotics resistant Klebsiella pneumoniae |
| title_sort |
prospective study on the efficiency of ciprofloxacin in combination with chloramphenicol and probiotics against multiple antibiotics resistant klebsiella pneumoniae |
| publisher |
BRAC University |
| publishDate |
2018 |
| url |
http://hdl.handle.net/10361/10440 |
| work_keys_str_mv |
AT ahmedakash aprospectivestudyontheefficiencyofciprofloxacinincombinationwithchloramphenicolandprobioticsagainstmultipleantibioticsresistantklebsiellapneumoniae AT ahmedakash prospectivestudyontheefficiencyofciprofloxacinincombinationwithchloramphenicolandprobioticsagainstmultipleantibioticsresistantklebsiellapneumoniae |
| _version_ |
1814309624586698752 |