| 000 | pam a22 i 4500 | ||
|---|---|---|---|
| 999 |
_c41954 _d41954 |
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| 001 | AALScienceDirectebook000009 | ||
| 003 | BD-DhAAL | ||
| 005 | 20191205134905.0 | ||
| 006 | m o d | ||
| 007 | cr cnu|||unuuu | ||
| 008 | 150928s2016 ne ob 001 0 eng d | ||
| 020 | _a0081001142 | ||
| 020 | _a9780081001141 | ||
| 020 | _z0081000944 | ||
| 020 | _z9780081000946 | ||
| 035 |
_a(OCoLC)922323918 _z(OCoLC)922918604 _z(OCoLC)929521751 _z(OCoLC)932328797 _z(OCoLC)951666431 _z(OCoLC)1066557439 |
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| 040 | _aBD-DhAAL | ||
| 050 | 4 | _aRM301.25 | |
| 060 | 0 | 0 | _a2015 L-371 |
| 060 | 1 | 0 | _aQV 38 |
| 072 | 7 |
_aMED _x071000 _2bisacsh |
|
| 082 | 0 | 4 |
_a615.1901 _223 |
| 245 | 0 | 0 |
_aConcepts and models for drug permeability studies : _bcell and tissue based In vitro culture models / _cedited by Bruno Sarmento. _h[electronic resource] |
| 260 | 1 |
_aAmsterdam : _bElsevier, _c2016. |
|
| 260 | 4 | _c�2016 | |
| 300 | _a1 online resource. | ||
| 490 | 1 |
_aWoodhead Publishing series in biomedicine ; _vnumber 79 |
|
| 500 | _a<strong>Off-Campus Access:</strong> Athens ID and Password Required | ||
| 500 | _a<strong>On-Campus Access:</strong> No User ID or Password Required | ||
| 504 | _aIncludes bibliographical references and index. | ||
| 505 | 0 | _aFront Cover; Related titles; Concepts and Models for Drug Permeability Studies; Copyright; Contents; List of contributors; List of figures; List of tables; 1 -- Introduction; 1.1 Introduction; References; 2 -- Importance and applications of cell- and tissue-based in vitro models for drug permeability screening in early stages o ...; 2.1 Introduction; 2.2 General considerations; 2.3 Drug transport; 2.3.1 Transport mechanisms; 2.4 Permeability-absorption models; 2.4.1 Physicochemical methods; 2.4.1.1 Physicochemical factors; 2.4.1.2 Immobilized artificial membrane chromatography | |
| 505 | 8 | _a2.4.1.3 Parallel artificial membrane permeability assay2.4.2 In vitro cell and tissue methods; 2.4.2.1 Cell-based methods; 2.4.2.2 Tissue-based methods; Diffusion chambers; Franz cells; Everted sacs; Isolated membrane vesicles; 2.5 Methods for permeability calculation; 2.6 Standardization of protocols for in vitro methods; 2.7 The "three Rs" principle; 2.8 Biosecurity systems; References; 3.1 -- Cell-based in vitro models for buccal permeability studies; 3.1.1 Introduction; 3.1.2 Physiology of the buccal mucosa; 3.1.3 Different in vitro models; 3.1.3.1 Hamster cheek pouch cells | |
| 505 | 8 | _a3.1.3.2 TR146 cell line3.1.3.2.1 Protocol; Cell culture conditions; Permeability studies; 3.1.3.3 Human oral keratinocytes; 3.1.3.3.1 Protocol; Oral keratinocyte culture conditions; Culturing on dead de-epidermized dermis (DDED); Permeability studies; 3.1.3.4 MatTek EpiOral"; 3.1.3.4.1 Protocol; Cell culture conditions; Permeability studies; 3.1.4 Conclusions; References; 3.2 -- Cell-based in vitro models for gastric permeability studies; 3.2.1 The stomach as a natural barrier to absorption; 3.2.2 Gastric drug delivery; 3.2.2.1 Molecular absorption in the stomach | |
| 505 | 8 | _a3.2.2.2 Physicochemical factors mediating stomach absorptive permeability3.2.3 Cellularized models of gastric permeability; 3.2.3.1 Protocol for establishing cellularized artificial models of the gastric wall; 3.2.4 Conclusions; Acknowledgments; References; 3.3 -- Cell-based in vitro models for intestinal permeability studies; 3.3.1 Anatomy and physiology of human small intestine; 3.3.1.1 Stromal-epithelial cross-talk; 3.3.2 Mechanisms of transport; 3.3.3 Intestinal barriers; 3.3.4 Intestinal in vitro models; 3.3.4.1 Caco-2 model; 3.3.4.1.1 Accelerated Caco-2 models | |
| 505 | 8 | _a3.3.4.1.2 Alternatives to the Caco-2 model3.3.4.2 Caco-2/HT29-MTX model; 3.3.4.3 Caco-2/Raji B model; 3.3.4.4 Caco-2/HT29-MTX/Raji B; 3.3.4.5 Novel 3D in vitro models; 3.3.5 Validation studies; 3.3.6 Conclusions; References; 3.4 -- Cell-based in vitro models for nasal permeability studies; 3.4.1 Introduction; 3.4.2 Nasal primary cell culture models; 3.4.2.1 Sampling approaches and procedures; 3.4.2.2 HNE cell preparation and culture initiation; 3.4.3 Immortalized nasal cell lines; 3.4.3.1 RMPI 2650 cell line; 3.4.3.2 BT cell line; 3.4.3.3 Human lung carcinoma cell line | |
| 506 | _aElectronic access restricted to authorized BRAC University faculty, staff and students | ||
| 538 | _aMode of access: Internet | ||
| 650 | 0 |
_aCell culture. _938039 |
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| 650 | 0 |
_aDrugs _xPhysiological transport _xResearch _xMethodology. _938040 |
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| 650 | 0 |
_aDrugs _xTesting. _938041 |
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| 650 | 0 |
_aEpithelial cells. _938042 |
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| 650 | 7 |
_aCell culture. _2fast _938039 |
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| 650 | 7 |
_aDrugs _xTesting. _2fast _938041 |
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| 650 | 7 |
_aEpithelial cells. _2fast _938042 |
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| 650 | 7 |
_aMEDICAL / Pharmacology _2bisacsh _938043 |
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| 650 | 1 | 2 |
_aPermeability. _938044 |
| 650 | 1 | 2 |
_aPharmacokinetics. _938045 |
| 650 | 2 | 2 |
_aCell Culture Techniques. _938046 |
| 650 | 2 | 2 |
_aModels, Biological. _938047 |
| 650 | 2 | 2 |
_aPharmaceutical Preparations _xmetabolism. _938048 |
| 650 | 2 | 2 |
_aTissue Culture Techniques. _938049 |
| 655 | 0 |
_aElectronic books. _938050 |
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| 655 | 4 |
_aElectronic books. _938050 |
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| 700 | 1 |
_aSarmento, Bruno, _eeditor. _938051 |
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| 776 | 0 | 8 |
_iPrint version: _z9780081000946 _z0081000944 _w(OCoLC)911073450 |
| 830 | 0 |
_aWoodhead Publishing series in biomedicine ; _vno. 79. _938052 |
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| 856 | 4 | 0 |
_zFull text available on ScienceDirect _uhttp://www.sciencedirect.com/science/book/9780081000946 |
| 942 |
_2ddc _cEBK |
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