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020 _a0128144246
020 _a9780128144244
020 _z0128144238
020 _z9780128144237
035 _a(OCoLC)1046633728
_z(OCoLC)1047806807
040 _aBD-DhAAL
050 4 _aRS200
072 7 _aMED
_x071000
_2bisacsh
082 0 4 _a615.19
_223
245 0 0 _aDosage form design considerations.
_nVolume 1 /
_cedited by Rakesh K. Tekade.
_h[electronic resource]
260 1 _aLondon, United Kingdom :
_bElsevier,
_c[2018]
300 _a1 online resource.
490 1 _aAdvances in pharmaceutical product development and research series
500 _a<strong>Off-Campus Access:</strong> Athens ID and Password Required
500 _a<strong>On-Campus Access:</strong> No User ID or Password Required
504 _aIncludes bibliographical references and index.
505 0 _aFront Cover; Dosage Form Design Considerations; Copyright Page; Dedication; Contents; List of Contributors; About the Editor; 1 Preformulation in Drug Research and Pharmaceutical Product Development; 1.1 Introduction; 1.1.1 An Overview of Formulation Life Cycle and Management; 1.1.2 Need of Preformulation: First Stage of Formulation Development; 1.1.3 Major Hurdles Impeding Successful Product Development; 1.1.4 Role of Preformulation During Product Development; 1.2 Parameters of preformulation studies; 1.2.1 Solubility; 1.2.2 The Permeability of the Drug
505 8 _a1.2.3 Bulk Characterization: Physical, Analytical, and Physicochemical1.2.4 Inherent Properties: pH, pKa, Log P, Log D, and Intrinsic Dissolution; 1.2.5 Stability: The Solution, Solid State, & ICH Photostability; 1.2.6 Drug-Excipient Compatibility; 1.2.7 Particle Size and Distribution; 1.2.8 Thermal Properties; 1.2.9 Hygroscopicity; 1.2.10 Bulk Properties; 1.2.11 Mechanical Properties and Compatibility; 1.2.12 Crystallinity and Polymorphism; 1.3 Role of preformulation in drug discovery; 1.3.1 Material Properties in Lead Selection, High Throughput Preformulation Studies
505 8 _a1.3.2 "Drugability" of New Chemical Entities1.3.3 Tools to Assist in Lead Selection; 1.4 Role of preformulation in drug development; 1.4.1 Identification of Challenges During Formulation Development: Pre-Assumptions; 1.4.2 The Dosage Form Specific Studies; 1.5 Preformulation studies of proteins and peptides; 1.6 Preformulation in vaccine development: Critical views; 1.7 Preformulation studies of packaging components; 1.8 Preformulation in 21st century: technological advancements; 1.8.1 Computerization and Aid of Software in the Preformulation Studies
505 8 _a1.8.2 Artificial Neural Network Tool Used in the Factorial Design: An Optimization Approach1.9 Case studies on preformulation of dosage forms; 1.10 Pharmacokinetics and preformulation: Point to note; 1.11 Rules and regulations in preformulation studies: Role of regulatory bodies; 1.12 Future remarks and conclusion; Acknowledgment; Abbreviations; References; Further Reading; 2 Physicochemical Aspects to Be Considered in Pharmaceutical Product Development; 2.1 Introduction; 2.2 Physical Characteristics of Solid Substances Used in Pharmaceutical Product Development
505 8 _a2.2.1 Crystalline Solid-State Substances2.2.1.1 Polymorphism; 2.2.1.2 Hydrates; 2.2.1.3 Solvates; 2.2.1.4 Cocrystals; 2.2.2 Amorphous Solids; 2.2.3 Particle Size; 2.2.4 Wettability; 2.2.5 Hygroscopicity; 2.3 Chemical Characteristics to be Considered in Pharmaceutical Product Development; 2.3.1 Degradation Reactions of Drugs; 2.3.1.1 Hydrolysis; 2.3.1.2 Dehydration; 2.3.1.3 Oxidation; 2.3.1.4 Photochemical Degradation; 2.3.1.5 Isomerization; 2.3.1.6 Polymerization; 2.3.1.7 Other Reactions; 2.4 Solubility Aspects in Pharmaceutical Products Development; 2.4.1 Aqueous Solubility
506 _aElectronic access restricted to authorized BRAC University faculty, staff and students
520 _aDosage Form Design Parameters, Volume I, examines the history and current state of the field within the pharmaceutical sciences, presenting key developments. Content includes drug development issues, the scale up of formulations, regulatory issues, intellectual property, solid state properties and polymorphism. Written by experts in the field, this volume in the Advances in Pharmaceutical Product Development and Research series deepens our understanding of dosage form design parameters. Chapters delve into a particular aspect of this fundamental field, covering principles, methodologies and the technologies employed by pharmaceutical scientists. In addition, the book contains a comprehensive examination suitable for researchers and advanced students working in pharmaceuticals, cosmetics, biotechnology and related industries.
538 _aMode of access: Internet
650 0 _aDrug delivery systems.
_937984
650 0 _aDrug development.
_937985
650 0 _aDrugs
_xDesign.
_937986
650 0 _aDrugs
_xDosage forms.
_937987
650 7 _aDrug delivery systems.
_2fast
_937984
650 7 _aDrug development.
_2fast
_937985
650 7 _aDrugs
_xDesign.
_2fast
_937986
650 7 _aDrugs
_xDosage forms.
_2fast
_937987
650 7 _aMEDICAL / Pharmacology.
_2bisacsh
_937988
655 4 _aElectronic books.
_937989
700 1 _aTekade, Rakesh K.,
_eeditor.
_937990
776 0 8 _cOriginal
_z0128144238
_z9780128144237
_w(OCoLC)1007038271
830 0 _aAdvances in pharmaceutical product development and research series.
_937991
856 4 0 _zFull text available on ScienceDirect
_uhttps://www.sciencedirect.com/science/book/9780128144237
942 _2ddc
_cEBK